GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs8102137 | 1 | rs59592823 | chr19:30297516 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 4.03 | 6.86E-5 | Bladder cancer |
| BLCA | cis | rs1109114 | 1 | rs59757169 | chr5:148618752 | AFAP1L1 | chr5:148651401-148721365:+ | 0.27 | 5.02 | 8.06E-7 | Body mass index |
| BLCA | cis | rs2243480 | 1 | rs59794892 | chr7:65415873 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.4 | 1.4E-5 | Diabetic kidney disease |
| BLCA | cis | rs8102137 | 1 | rs59868991 | chr19:30297577 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 4.03 | 6.86E-5 | Bladder cancer |
| BLCA | cis | rs8078723 | 1 | rs59925331 | chr17:38169273 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.95 | 9.21E-5 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs60843830 | 1 | rs59937473 | chr2:271797 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.7 | 3.03E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs1930961 | 1 | rs5996946 | chr22:25875988 | CRYBB2 | chr22:25615612-25627836:+ | 0.93 | 9.86 | 1.33E-20 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs7714584 | 1 | rs59980321 | chr5:150241813 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 5.62 | 3.62E-8 | Crohn's disease |
| BLCA | cis | rs6003958 | 1 | rs6003958 | chr22:24264089 | GSTT1 | chr22:24376141-24384284:- | -0.63 | -9.02 | 9.47E-18 | S-phenylmercapturic acid levels in smokers |
| BLCA | cis | rs6003958 | 1 | rs6003958 | chr22:24264089 | GSTT2 | chr22:24322314-24326104:+;chr22 | 0.49 | 6.36 | 5.7E-10 | S-phenylmercapturic acid levels in smokers |
| BLCA | cis | rs6003958 | 1 | rs6003958 | chr22:24264089 | LOC391322 | chr22:24373117-24374043:+ | -0.53 | -8.05 | 1.06E-14 | S-phenylmercapturic acid levels in smokers |
| BLCA | cis | rs1930961 | 1 | rs6004667 | chr22:25874464 | CRYBB2 | chr22:25615612-25627836:+ | -0.9 | -9.22 | 2.0E-18 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs1930961 | 1 | rs6004668 | chr22:25874502 | CRYBB2 | chr22:25615612-25627836:+ | -0.97 | -10.49 | 8.42E-23 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs1930961 | 1 | rs6004669 | chr22:25875803 | CRYBB2 | chr22:25615612-25627836:+ | 0.95 | 10.08 | 2.42E-21 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs1930961 | 1 | rs6004671 | chr22:25879474 | CRYBB2 | chr22:25615612-25627836:+ | 0.91 | 9.5 | 2.28E-19 | Bipolar disorder with mood-incongruent psychosis |